The substance abuse makes an interesting comparison. The big divider is Hawkeye's perceived humanism vs House's misanthropy, however, I think the case can be made that there's less distance than you'd think Hawkeye is determined to save individual patients and fight the dehumanizing effects of the war, but it's not clear that he's got all that high opinion of humanity in general, whereas House, much as it pains me to admit, may not be quite as much of a humanity-hater as he likes to put up. We can't blame all of his posturing on the leg or Stacy or even Dad, but there are clues that there's a bit of sweetness if not actual mush lying under the surface.